In the earlier stages of the game, there are a few cabinets of the original Area 51 arcade game, complete with red and blue light-guns.

On the HOT ZONE mission at the beginning of the level.Hidden in a corner there is the original AREA 51 arcade game complete with red and blue lasar-light guns.

Complete the game on normal difficulty to unlock the hard difficulty.

During the training levels, scan everyone that you can. You will find some interesting equipment of the MPs, including adult diapers and condoms. Hold right analog-stick Down (with the default controller configuration, or in the opposite direction in the inverted configuration) until your scanner stops moving and you appear to be looking at your feet. You can now scan yourself and see information about Cole.

When you reach "Lies of the Past: Checkpoint 4", you will ascend in an elevator. Exiting the elevator, you will see a replica of the Moon's surface, a model of the U.S. space suit, and a shuttle the United States used to reach the Moon. This is in reference to the Moon Landing Conspiracy, claiming that the U.S. never actually reached the Moon, and faked the landing to beat the Russians in the space race. The conspiracy was heavily debated, but ultimately rejected by the majority of opinions. Today, only a few people still claim the Moon landing was a hoax.

In the level "The Grays" proceed into the 4th room in the level, where you can see the monorail you entered the level from out the window. Push the computer console there and it will say "Lifter activated". Make your way back outside to the monorail, you can now stand on it. Run all the way to the back of it and you will be warped to a weird room with sharks that have machine guns attached to their heads.

Grab all the other secrets to unlock the final secret (page 5). Well, d'uh.

Beat the Campaign mode on the Hard difficulty setting to unlock an alien Gray as a selectable multi-player avatar.

Scanning all five databank items in each stage yields one secret. Completing the game yields one secret.

In the stage Life or Death, there is a small key on a dead soldier in one of the lifts where Cole starts the stage. Grab it to open the small lockers in the stage. One of the small lockers in the first power conduit pit has a databank item that upgrades the alien grenade (it now homes in on enemies).