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Never use the pulse grenades in closed compartments or near essential pickups (pickups are destructible). If you are surrounded or trapped, use the burst fire.
Ignore all the Weyland-Yutani canisters strewn all over the level. None of these contain anything of value.
Ignore searching for loot inside crates. There are no destructible crates.
Steam does not hurt. Smoking does...
Do not try to open doors that are locked. There is no way you can open these.