Use the D-pad and Analog-stick together to aim faster than normal.

When Ashley is on a cliff or still up a ladder, you can aim your gun up at her. She will grab her skirt and call you a pervert.

To avoid getting hurt by traps such as explosives and bear traps, use your laser sight and shoot at the explosive or the middle of the trap.

After you survive the raid, you must choose a path to open; left or right. Open the right gate and it will take you to El Gigante. Use the shotgun and make the boulder drop down on his head when he arrives. Then, turn around and kick the door six times to knock the chains off it. If you are still standing outside the door when you see Gigante approach you from behind, do not panic; just get out of there quickly. He does not attack for a few seconds after he comes up behind you. The knife or a gunshot may help destroy the chains quicker, but kicking works. Go through another door in the same fashion and somewhere along the way you should find a key. It may be in one of the last huts you see toward the center. If you are quick enough, you can escape El Gigante and make it through the door alive with Ashley.

You can kill the fish and use them as recovery items in the sewer area shortly after the beginning of Chapter 1-2. It is a little after the place where you face the two enemies who throw dynamite at you.

When you are in the area where you are just about see the intermission sequence with Luis dying, there will be a door that lets you know that you will need another person for it. After you get Ashley back, return to this door. Give Ashley a piggyback and she will open the door. Inside will be a lot of treasure, and the powerful Broken Butterfly. You do not have to buy it from the merchant or sell it for money. Additionally, the strongest Magnum is not the Killer 7. When you tune up and buy the exclusive option of the Broken Butterfly its power will increase to 50.0, far stronger than the Killer 7's 35.0. You can kill a Boss in four shots.

When you enter the town, kill everyone. When the second wave of people arrives, also kill all of them. You can then go into the house and they will not come out. Additionally, during the mine cart section of Chapter 4-2, the mine car will stop and lots of enemies and two chainsaw men will load into the stopped cars. To avoid most of this encounter, be in the front car and immediately shoot the switch. The cars will start moving, and you will have only have about four enemies to kill.

Before the end of the chapter, there is a puzzle in the church. The puzzle is a simple mix of colors. Three different designs surround the main design. The colors are red, green, and blue. When you enter the church, turn to the left and go down the little hall. Climb the ladder. When you are up there, you will see that the way to the door is barred. You must get to the other side of the church by jumping on and off of the chandelier. On the other side, there is a set of switches. When you activate it, the puzzle starts. The goal is to turn the designs so when combined, they are the same as the middle design. Turn red twice, green three times, and blue once. When combined, it should create the design. Then, go in and grab Ashley.

The quickest way to complete the puzzle when playing as Ashley in Chapter 3-4 is as follows. The layout of the puzzle's squares is referred as:

1 2 3
4 5 6
7 8 9

Press X on the following in this order: 4, 7, 8, 9, 6, 3, 1, 7, 9.

Kill Salazar's "right hand" that you need to use the liquid nitrogen tanks on to receive the "Crown Jewels". which fit into the "Crown" treasure item. This is difficult; try using the Chicago Typewriter.

When you meet a man with the chainsaw, shoot him with the shotgun and incendiary grenades. You can also use your handgun, but you will probably get killed. Note: The shotgun is found in the building that is diagonal from the tower.

When you start, Del Lago is towing you and heading toward the pieces of land in the middle. Steer to avoid them and harpoon him as soon as you can afterwards (before it lets go). Next, aim a harpoon and throw it at any sign of movement so that you will not be knocked off the boat. After awhile it will go away, then charge at the boat. Throw as many harpoons at it as possible before it reaches the boat. If you get knocked out, press X until you get back in. Repeat this process until the intermission sequence starts and Del Lago retreats.

The zombie dogs are brown colored. You will find one in the beginning. The zombie dogs will not attack you until you meet Chief Mendez. The dogs will have parasites sticking out of them after chapter 3. A shotgun will kill them easily. Note: Do not kill the white dog in the trap. It will help you fight the Gigante.

Either weapon works; feel free to experiment. When the battle starts, check out the shacks and get all of the items that you can. When he gets close, run between his legs, get behind him, then open fire. When he is approaching you, use the shotgun and keep shooting him in the head while avoiding his attacks. When he roars and starts moving around, something will pop out of his back. Before it kneels on the ground, get in close until the action command that reads "Climb" appears. Use it to get on his back. The screen will indicate which button to use to slash. Press that button as fast as possible until you get off. Repeat the process one to three more times to defeat him. Additionally, when facing the El Gigante, buy a rocket launcher; it will kill him in one hit instead of wasting your other ammunition.

You will have to fight four El Gigantes (the big monster that breaks through the door and picks up and crushes Leon). You will fight one by yourself, one with the girl, and two at the same time by yourself. The quickest way to kill them is to buy a rocket launcher immediately before the fight so that you do not take waste space in you inventory. Throw a flash grenade to stun him, then run around behind and shoot him in the back. You will kill him in one hit. The same can also be done on most of the Bosses. If this does not kill them, it will do a lot of damage.

To win easily against the two El Gigantes in Chapter 4-2, go up the ladder and go down the rope on the other side of the room to activate the mechanism. It will open the circle in the middle of the room and take an El Gigante into the lava. Do not try it a second time; the mechanism will not work again. Just use the rocket launcher to finish the remaining El Gigante.

If you are on a bridge and there are open areas, take out a weak gun. One shot will make them fall off the bridge. However, you will not get any items from them.

If you are able to hit the flying insect enemies in the cave area while they are airborne, they will die in just one hit. Any weapon works, though the shotgun is recommended. This will help conserve your ammunition. If they manage to land, you will use about three to four shogun rounds from a Stock Striker (firepower 6.0).

When you are in the castle and you fire at the Gothic Illuminados, it is best to fire at their knees. They will fall on them and allow you to use a suplex move instead of a kick. You will then throw them over your head and smash their head in the ground. Note: In mercenary mode, the same goes for the rest of the mercenaries.

If you are low on ammunition, try to avoid these enemies. The zombies have orange eyes. When killed, the parasite in them will come out of their heads. Stay away from it and shoot it from a distance. If you are too close, the parasite will cut your head off.

Try not to get surrounded by them. Make sure they are in a group. Take out whatever rifle you have and shoot them all in the head until the snake thing appears. Wait until they are all like, then throw a flash grenade to kill all of them at once. This works well on all of them, and saves ammunition.

You do not need a special scope to kill them. Buy the Killer 7 Magnum and use it on them. After three or four shots, they will go down. Shoot it in the sheet until there is a hole. Then, shoot its head. After that, the body will explode then the legs will fall over and leave 5,000 gold. Additionally, another way to kill the Regenerator creatures is to shoot their head or chest with the shotgun. Then, blast a leg away; it will fall on the ground. Then, take out an incinerator grenade (the red ones) and throw it at them. If done correctly, he will burn on the ground and die.

In the area where Ashley is carried away by the flying insects, you can destroy the nest that is hanging from the ceiling. After it is destroyed, you will find a lot of green and red eyes, and if you are lucky, even a blue one. This is a good way to get the Butterfly Lamp filled with all three jewels early so that you can get some extra money for upgrades.

After you kill the hatchet guy as soon as you start the game, go upstairs to the window. Do not jump out. Instead, take out your pistol and shoot the glass out. Then, carefully aim for the villagers' heads that are awaiting outside. There are three of them. If you kill all three, you can jump out and avoid any damage.

Once you gain access to the tunnel with the merchant beyond Pueblo, return to the farm area and wait for the chickens there to lay eggs. Exit and re-enter to begin the same process over again. After you fill your inventory, you can return to the nearby merchant to sell your eggs. White chicken eggs sell for 300 Pesetas, brown eggs for 600 Pesetas, and golden eggs for 3,000 Pesetas.

Fully upgrade the Handcannon's firepower, reload, and capacity. The 'exclusive' option then raises the attack power to 99.9 and gives infinite ammo.

In Chapter 1-3 in the church, turn right. Go to the small path at the back of the church. You will see a blinking object. Get near it, then press X to check. After that, first rotate seven times using option 3, another five times using option 4, then one more time with option 3. You will hear a sound and can now get the Green Catseye.

At the beginning of the game, if you leave a hen alone in Pueblo they should lay at least one golden egg (which fully restores health when used). Go to the weapon/health screen and select the egg. It should allow you to equip the egg. At the screen, Leon will throw the egg up and down, looking smug. Additionally, the golden egg is the best healing item, as it fully heals you and only takes one space in your case.

In Professional difficulty, everything is the same except for the fact that enemies are alot tougher to kill. To unlock it just finish the game once.

When you first get to the church, defeat everyone in the area. Then, return to the church and shoot the bell above. Villagers will arrive in a groups of three to six Gonados. You can continue this process as much as desired.

Note: Save your game before each encounter when trying to see the following death scenes:

Betrayal: When you are in the cabin surrounded by Ganados, shoot Luis Sera about five to eight times. An intermission sequence will begin.

Chief Mendez: In the barn fight, do not evade his grab in the intermission sequence.

Del Lago (before fighting him): Stand on the dock by the lake where you fight the giant alligator (Del Lago). Fire your shotgun into the water several times. Eventually, Del Lago will come out and eat you.

Del Lago (when fighting him): After getting knocked out of the boat, swim back until you are just in reach of the boat. Del Lago will appear from underneath. Additionally, after killing Del Lago, do not cut the rope.